Predicting novel features of toll-like receptor 3 signaling in macrophages.
The Toll-like receptor (TLR) 3 plays a critical role in mammalian innate immune response against viral attacks by recognizing double-stranded RNA (dsRNA) or its synthetic analog polyinosinic-polycytidylic acid (poly (IratioC)).This leads to the activation of MAP kinases and NF-kappaB which results in the induction of type I interferons and proinfla